Pretty much the best part, for me anyway, was the line along the lines of “Sam and Dean have gone hunting, and they haven't been home in a few days.” A nice little nod, and a good way to get all the ladies together.
I'm not sure I dig Claire as the lead. I would rather see Jody as the main character, and I just hope to hell that they don't decide to kill her off.
I'd have been perfectly happy with a women-centric monster-of-the-week show, although I like centering on Jody and all the girls she's helped (and maybe more in the future?). I don't know that I like this whole new dimension, predator-bane monsters, and evil!Kaia twist at the end. I hope my doubts prove wholly unfounded, but … yeah, ambivalent is just the word I'm left with.
I still hope it gets picked up, and I hope it's an awesome pro-women SPN-like show, with all the humor and general flavor of the original.